Mahoney Center for Neuro-Oncology

Functional Genomic Atlas of the Mouse Brain
--An In Situ Hybridization Database of Transcription Factors and RNA-Binding Proteins


Mouse Brain Organization Revealed through Direct Genome Scale Transcription Factor Expression Analysis

In the developing brain, transcription factors (TFs) direct formation of a diverse array of neurons and glia. We identify 1445 putative TFs in the mouse genome.  We used in situ hybridization to map the expression of over 1000 of these TFs and TF coregulator genes in the brains of developing mice.  We find that 349 of these genes show restricted expression patterns adequate to describe the anatomical organization of the brain.  We provide a comprehensive inventory of murine TFs and their expression patterns in a searchable brain atlas database.
24 December 2004 of Science, Vol. 306, No. 5705